Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products

Aerodynamic particle size characteristics of orally inhaled products (OIPs) are critical to their performance. Testing based on cascade impaction has been the primary tool used to characterize this critical quality attribute and is a regulatory expectation for Quality Control purposes. In recent years, there have been substantial efforts directed at improving aerodynamic particle size determinations. Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products brings together for the first time a review of best practices for performing cascade impactor testing with a thorough discussion of the recently introduced concepts of abbreviated impactor measurements (AIM) and efficient data analysis (EDA). Topics covered include: · Review of pharmacopeial methods (US and European) for assessment of aerodynamic particle size distribution (APSD) of OIPs. · Physical processes that underlie aerosol formation from OIPs and the mechanisms that affect the APSD. · Good cascade impactor practice (GCIP) related to either full resolution or abbreviated impactor measurements. · Introduction of the AIM and EDA concepts. · Selection of the type of testing through the development lifecycle of